Evaluation of Serum Brain-derived Neurotrophic Factor (BDNF) in Ambulatory Stroke Survivors With Mild Cognitive Impairment and Normal Cognitive Functions

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Published: Nov 30, 2024
DOI: https://doi.org/10.47836/mjmhs.20.6.32
Keywords:
Age-related decline, Cardiovascular risk, Neurotrophic factor, Obesity, Rehabilitation

Main Article Content

Mohd Ariff Sharifudin
Department of Orthopaedics, Traumatology and Rehabilitation, Faculty of Medicine, Universiti Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400 Kuala Terengganu, Terengganu, Malaysia
Abdulkareem Muhammad Umar
Department of Human Physiology, Faculty of Basic Medical Sciences, Federal University Dutse, 720223 Jigawa, Nigeria
Naresh Bhaskar Raj
School of Rehabilitation Science, Faculty of Health Sciences, Universiti Sultan Zainal Abidin, 21300 Kuala Nerus, Terengganu Malaysia
Aisha Ahmad Ahmad
Department of Physiotherapy, Faculty of Allied Health Science, Bayero University, 700241 Kano, Nigeria

Abstract

Introduction: This study aims to assess serum brain-derived neurotrophic factor levels in ambulating stroke patients, focusing on potential correlations with cardiovascular risk factors and overall obesity. Materials and methods: Sixty stroke patients (63.3% male, 36.7% female, mean age: 57 years) participated. Quantikine ELISA kit (SL0371Hu) was used to determine post-stroke serum brain-derived neurotrophic factor levels. Patient demographics, including body mass index, systolic, and diastolic blood pressures, were recorded and computed to assess patients' overall obesity status and blood pressure. Results: The mean serum brain-derived neurotrophic factor level was 119.25 (SD = 11.40) pg/ml. No significant effect of selected anthropometric indices and cardiovascular risk factors, including age (p = 0.493), overall obesity status (p = 0.848), systolic and diastolic blood pressures (p = 0.840 and 0.540, respectively), on the serum brain-derived neurotrophic factor. Conclusion: In ambulating stroke patients, the serum brain-derived neurotrophic factor levels were within the normal range but tended towards the lower limit. Consequently, it is crucial to develop and implement medical and rehabilitation programs specifically aimed at increasing serum brain-derived neurotrophic factor levels in post-stroke patients.

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Sharifudin, M. A., Umar, A. M., Bhaskar Raj, N., & Ahmad, A. A. (2024). Evaluation of Serum Brain-derived Neurotrophic Factor (BDNF) in Ambulatory Stroke Survivors With Mild Cognitive Impairment and Normal Cognitive Functions. Malaysian Journal of Medicine and Health Sciences, 20(6), 242–249. https://doi.org/10.47836/mjmhs.20.6.32
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Vol. 20 No. 6 (2024)
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Original Articles
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