A Review of Clinical and Pharmacogenetic Relationship Between Statin Use, Diabetes Mellitus, and Erectile Dysfunction

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Published: May 31, 2024
DOI: https://doi.org/10.47836/mjmhs.20.3.43
Keywords:
Statins, erectile dysfunction (ED), diabetes mellitus, genetics, Testosterone

Main Article Content

Naam Bahjat Ahmed Adeeb
School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Ruzilawati Abu Bakar
School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Nur Aizati Athirah Daud
School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.
Hadeer Alani
School of Medicine, University of California (Davis), 4610 X Street, Sacramento, CA 95817, USA.
Dzul Azri Mohamed Noor
School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 USM, Pulau Pinang, Malaysia.
Imran Ahmad
School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Zilfalil Bin Alwi
School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

Abstract

This study aimed to highlight the genetic and clinical associations among the statins, diabetes mellitus, and erectile dysfunction. Statins are regarded as the first-line therapy for dyslipidemia management and an essential medicine for controlling other cardiovascular risks. Several studies have found evidence of links between chronic statin use, diabetes mellitus, and reduction of sperm quality in humans; however, the mechanism of action has not been thoroughly investigated. Clinical studies showed evidence for the impact of statins on the diabetes mellitus, which in turn worsened the erectile dysfunction. This chain is discussed in the present literature study. There are 44 genes associated with statin pharmacodynamics, which are primarily classified as cholesterogenic and lipogenic genes. Statins have a negative effect on the genes that produce testosterone. These genes suppress the production and release of the testosterone hormone, which is considered the leading cause of erectile dysfunction. There is a lack of evidence on the genetic role of erectile dysfunction in statin use, which necessitates additional research on this topic. Furthermore, the effect of comorbidities such as diabetes mellitus should be studied among different ethnicities as an influencing factor to better understand the screening and prevention of patients with genetic risk factors and to support the investigation of future genetic therapies. This study concluded the significance of the genetic influence of statins and diabetes melilites on the erectile dysfunction.

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How to Cite
Ahmed Adeeb, N. B., Abu Bakar, R., Athirah Daud, N. A., Alani, H., Mohamed Noor, D. A., Ahmad, I., & Bin Alwi, Z. (2024). A Review of Clinical and Pharmacogenetic Relationship Between Statin Use, Diabetes Mellitus, and Erectile Dysfunction. Malaysian Journal of Medicine and Health Sciences, 20(3), 320–326. https://doi.org/10.47836/mjmhs.20.3.43
Issue
Vol. 20 No. 3 (2024)
Section
Review Article
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Europe PMC

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