Ethnobotany, Phytochemistry and Pharmacology of Acanthus ilicifolius: A Comprehensive Review
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Abstract
Acanthus ilicifolius (family Acanthaceae) is a well-known mangrove plant that is commonly found in India, Australia, and Southeast Asia countries. In this review, this plant is discussed to provide a comprehensive database on its ethnobotanical aspects, as well as phytochemicals, and pharmacological activities. The findings summarised that A. ilicifolius contains mainly flavonoids, alkaloids, and various glycosides. The phytochemicals isolated from the plant have been scientifically proven to possess medicinal properties such as antibacterial, anti-inflammatory, antioxidant, antidiabetic, anticancer, anti-acne, anti-helminthic, anti-allergic, and anti-asthmatic properties. This study provides comprehensive and updated data on the phytoconstituents and pharmacological activities of A. ilicifolius’s from various research. This information is important for future research exploration on the plant especially in the investigation of the efficacy and safety of the plant’s compounds toward the application in treating diseases.
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Saranya A, Ramanathan T, Kesavanarayanan KS, Adam A. Traditional medicinal uses, chemical constituents and biological activities of a mangrove plant, Acanthus ilicifolius Linn.: A brief review. American-Eurasian Journal of Agriculture and Environmental Science, 2015; 15: 243-250. doi: 10.5829/idosi.aejaes.2015.15.2.12529
Andriani D, Revianti S, Prananingrum W. Identification of compounds isolated from a methanolic extract of Acanthus ilicifolius leaves and evaluation of their antifungal and antioxidant activity. Biodiversitas Journal of Biological Diversity. 2020; 21(6): 2521-2525. doi: https://doi.org/10.13057/biodiv/d210625
Ahmad WJ, Ahmad N, Mohamed AL. Mangrove Flora of Malaysia: Malaysia Biodiversity Information System (MyBIS). Malaysia Biodiversity Information System (MyBIS). Penerbit Universiti Kebangsaan Malaysia; 2018: 100.
MyBIS. Malaysia Biodiversity Information System. Ministry of Energy and Natural Resources, Malaysia Biodiversity Centre & Forest Research Institute Malaysia, 2022. [Retrieved 20 April 2023]. Available from:https://www.mybis.gov.my/art/2508
Basyuni M, Siagian YS, Slamet B, Sulistiyono N, Putri LA, Yusraini E, Lesmana I. Leaf nutrition content and organoleptic of Jeruju (Acanthus ilicifolius L) and processed products in Lubuk Kertang Village, North Sumatera. In IOP Conference Series: Earth and Environmental Science 2019; 374(1): 012052. doi:10.1088/1755-1315/374/1/012052
Bose S, Bose A. Antimicrobial activity of Acanthus ilicifolius (L.). Indian journal of pharmaceutical sciences. 2008; 70(6): 821-823. doi: 10.4103/0250-474X.49134
Sardar PK, Dev S, Al Bari MA, Paul S, Yeasmin MS, Das AK, Biswas NN. Antiallergic, anthelmintic and cytotoxic potentials of dried aerial parts of Acanthus ilicifolius L. Clinical Phytoscience. 2018; 4(34): 1-3. doi: 10.1186/s40816-018-0094-7
Singh D, Aeri V. Phytochemical and pharmacological potential of Acanthus ilicifolius. Journal of Pharmacy & Bioallied Sciences. 2013; 5(1): 17. doi: 10.4103/0975-7406.106557
Babu BH, Shylesh BS, Padikkala J. Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia. 2001; 72(3): 272-277. doi: 10.1016/s0367-326x(00)00300-2
Bandaranayake WM. Bioactivities, bioactive compounds and chemical constituents of mangrove plants. Wetlands Ecology and Management. 2002; 10: 421-452. doi:10.1023/A:1021397624349
Giesen W, Wulffraat S, Zieren M, Scholten L. Mangrove guidebook for Southeast Asia. Mangrove guidebook for Southeast Asia. 2007.
Senthil Kumar KT, Puia Z, Samanta SK, Barik R, Dutta A, Gorain B, Roy DK, Adhikari D, Karmakar S, Sen T. The gastroprotective role of Acanthus ilicifolius – A study to unravel the underlying mechanism of anti-ulcer activity. Scientia Pharmaceutica. 2012; 80(3): 701-718. doi: 10.3797/scipharm.1108-11
Sari Nindhia T, Gde Tirta Nindhia T, Nyoman Trisnawati N. Data on Potential of Indonesian variety of Sea holly (Acanthus ilicifolius Linn) as Herbal Medicine. In 2020 4th International Conference on Computational Biology and Bioinformatics. 2020; 27 (52-56).
Pattanaik C, Reddy CS, Dhal NK, Das R. Utilisation of mangrove forests in Bhitarkanika wildlife sanctuary, Orissa. Indian Journal of Traditional knowledge. 2008; 7(4): 598-603
Van Kiem P, Quang TH, Huong TT, Nhung LT, Cuong NX, Van Minh C, Choi EM, Kim YH. Chemical constituents of Acanthus ilicifolius. L. and effect on osteoblastic MC3T3E1 cells. Archives of Pharmacal Research. 2008; 31: 823-829. doi: 10.1007/s12272-001-1232-3
Chakraborty T, Bhuniya D, Chatterjee M, Rahaman M, Singha D, Chatterjee BN, Datta S, Rana A, Samanta K, Srivastawa S, Maitra SK. Acanthus ilicifolius plant extract prevents DNA alterations in a transplantable Ehrlich ascites carcinoma-bearing murine model. World Journal of Gastroenterology: WJG. 2007; 12;13(48):6538.
Azam K, Nur M, Rahman MM, Biswas S, Ahmed MN. Appraisals of Bangladeshi medicinal plants used by folk medicine practitioners in the prevention and management of malignant neoplastic diseases. International Scholarly Research Notices Volume. 2016; 1-12. doi.org/10.1155/2016/7832120
Madureira MC, Martins AP, Salgueiro L, Paiva J, Proença da Cunha A. Medicinal plants, and traditional medicine in the Gulf of Guinea–S. Tomé and Príncipe islands. Recent progress in medicinal plants. 2002; 7: 361-381.
Giesen W, Wulffraat S, Zieren M, Scholten L. Mangrove guidebook for Southeast Asia. Mangrove guidebook for Southeast Asia. 2007; 769.
Bora R, Adhikari PP, Das AK, Raaman N, Sharma GD. Ethnomedicinal, phytochemical, and pharmacological aspects of genus Acanthus. International Journal of Pharmacy and Pharmaceutical Science. 2017; 9 (12): 18-25. doi:10.22159/ijpps.2017v9i12.22386.
Zhang QW, Lin LG, Ye WC. Techniques for extraction and isolation of natural products: a comprehensive review. Chinese Medicine. 2018; 13: 20 https://doi.org/10.1186/s13020-018-0177-x
Abubakar AR, Haque M. Preparation of Medicinal Plants: Basic Extraction and Fractionation Procedures for Experimental Purposes. Journal of Pharmacy & Bioallied Sciences, 2020; 12(1): 1–10. https://doi.org/10.4103/jpbs.JPBS_175_19
Govindasamy C, Arulpriya M. Antimicrobial activity of Acanthus ilicifolius: Skin infection pathogens. Asian Pacific Journal of Tropical Disease. 2013; 3(3): 180-183. doi: 10.1016/S2222-1808(13)60036-5
Wu J, Zhang S, Huang J, Xiao Q, Li Q, Long L, Huang L. New aliphatic alcohol and (Z)-4-coumaric acid glycosides from Acanthus ilicifolius. Chemical and Pharmaceutical Bulletin. 2003; 51(10): 1201-1203. doi: 10.1248/cpb.51.1201
Mondal M, Torequl Islam M, Zaman Smrity S, Rouf R. Preliminary Phytochemical and Anti-Bacterial Sensitivity Test of Ethanolic Stem Bark Extract of Acanthus ilicifolius. L.). Journal of Pharmaceutical and Applied Chemistry. 2021; 7(1): 35-38. doi: 10.18576/jpac/070105
Nusaibah N, Pangestika W, Herry H. Utilization of jeruju leaves extract (Acanthus ilicifolius) as a raw anti-acne cream. Agrikan: Jurnal Agribisnis Perikanan. 2021; 14(1): 16-24. doi: 10.29239/j.agrikan.14.1.16-24
Vani M, Manikandan T. GC–MS analysis for compound identification in leaf extract of Acanthus ilicifolius and evaluation of its in vitro anticancer effect against MCF-7 cell lines. International Journal of Development Research. 2019; 9(12): 32571-32575.
Gong CF, Wang YX, Wang ML, Su WC, Wang Q, Chen QX, Shi Y. Evaluation of the structure and biological activities of condensed tannins from Acanthus ilicifolius Linn and their effect on fresh-cut Fuji apples. Applied Biochemistry and Biotechnology. 2019; 189: 855-870. doi: 10.1007/s12010-019-03038-6
Zheng G, Chen T, Peng X, Long S. Synthesis, anti-inflammatory, and analgesic activities of derivatives of 4-Hydroxy-2-benzoxazolone. Journal of Chemistry. 2015; 534516: 1-5. doi: 10.1155/2015/534156
Hasui T, Matsunaga N, Ora T, et al. Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists. Journal of Medicinal Chemistry. 2011;54(24):8616-8631. doi:10.1021/jm2011645
Li MY, Xiao Q, Pan JY, Wu J. Natural products from semi-mangrove flora: source, chemistry and bioactivities. Natural Product Reports. 2009; 26(2): 281-298. doi: 10.1039/b816245j
Hashimoto Y, Shudo, K. 1996. Chemistry of biologically active benzoxazinoids. Phytochemistry, 1996; 43(3): 551-559. https://doi.org/10.1016/0031-9422(96)00330-5
Razavi SM, Zahri S, Zarrini G, Nazemiyeh H, Mohammadi S. Biological activity of quercetin-3-O-glucoside, a known plant flavonoid. Bioorganicheskaia Khimiia. 2009;35(3):414-416. doi:10.1134/s1068162009030133
Tan D, Jiang C, Tao Y. Chemical constituents of Acanthus ilicifolius. Chemistry of Natural Compounds. 2016; 52(5): 951-952. doi: 10.1007/s12272-001-1232-3
Wöstmann R, Liebezeit G. Chemical composition of the mangrove holly Acanthus ilicifolius (Acanthaceae): Review and additional data. Senckenbergiana maritima. 2008; 38(1): 31-37. doi: 10.1007/BF03043866
Wu J, Zhang S, Xiao Q, Li Q, Huang J, Long L, Huang L. Megastigmane and flavone glycosides from Acanthus ilicifolius. Die Pharmazie-An International Journal of Pharmaceutical Sciences. 2003; 58(5): 363-364.
Kanchanapoom T, Kamel MS, Kasai R, Yamasaki K, Picheansoonthon C, Hiraga Y. Lignan glucosides from Acanthus ilicifolius. Phytochemistry. 2001; 56(4): 369-372. doi: 10.1016/s0031-9422(00)00362-9
Naher K, Moniruzzaman M, Islam S, Hasan A, Paul GK, Jabin T., ... & Uddin MS. Evaluation of biological activity and in silico molecular docking studies of Acanthus ilicifolius leaf extract against four multidrug-resistant bacteria. Informatics in Medicine Unlocked, 2022; 33: 101092.
Nga TT, Thi Hoan L, Anh BTM, Mai NT, Huong PTT, Nhiem NX, Kiem PV, Tai BH. Two new lignan glycosides from Acanthus ilicifolius L. with their NO inhibition and cytotoxic activity. Natural Product Research, 2023; 1-9.
Huo, C., Liang, H., Tu, G., Zhao, Y., & Lin W. A new 5, 11-epoxymegastigmane glucoside from Acanthus ilicifolius. Natural Product Research. 2008; 22(10): 896–900. doi: 10.1080/14786410701642680
Raut S, Khan S. Phytochemical fingerprinting of Acanthus ilicifolius. Linn. Advanced Plant Science. 2012; 25: 749-753.
Rahmatullah M, Samarrai W, Jahan R, Rahman S, Sharmin N, Miajee EU, ... & Ahsan, S. An ethnomedicinal, pharmacological and phytochemical review of some Bignoniaceae family plants and a description of Bignoniaceae plants in folk medicinal uses in Bangladesh. Advances in Natural and Applied Sciences. 2010; 4(3): 236-253.
Firdaus M, Prihanto AA, Nurdiani R. Antioxidant and cytotoxic activity of Acanthus ilicifolius flower. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(1):17-21. doi: 10.1016/S2221-1691(13)60017-9
Jonathan EM, Okieimen FE. Extraction of Stigmasterol and β-Sitosterol from the leaves of Acanthus montanus and their contractile activity on uterine muscles of non-pregnant female albino rats. Journal of Chemical Society of Nigeria. 2020; 45(6).
Acero N, Muñoz-Mingarro D, Navarro I, León-González AJ, Martín-Cordero C. Phytochemical Analysis and Anti-Inflammatory Potential of Acanthus mollis L. Rhizome Hexane Extract. Pharmaceuticals. 2023; 16(2): 159.
Basyuni M, Harahap FK, Wati R, Putri LAP, Effect of mangrove rehabilitation on socio-cultural of Pulau Sembilan society, North Sumatera, Indonesia. IOP Conference Series: Earth Environmental Science. 2018;126:012115.
Pothiraj C, Balaji P, Shanthi R, Gobinath M, Suresh Babu R, Munirah AAD, et al. Evaluating antimicrobial activities of Acanthus ilicifolius L. and Heliotropium curassavicum L. against bacterial pathogens: an in-vitro study. Journal of Infection and Public Health. 2021;14(12):1927-1934. doi:10.1016/j.jiph.2021.10.013
Basyuni M, Siagian YS, Slamet B, Sulistiyono N, Putri LAP, Yusraini E, Lesmana I. Leaf nutrition content and organoleptic of Jeruju (Acanthus ilicifolius L) and processed products in Lubuk Kertang Village, North Sumatera. IOP Conference Series: Earth and Environmental Science. 2019;374(1):012052. doi:10.1088/1755-1315/374/1/012052
Almagrami AA, Alshawsh MA, Saif-Ali R, Shwter A, Salem SD, Abdulla MA. Evaluation of chemopreventive effects of Acanthus ilicifolius against azoxymethane-induced aberrant crypt foci in the rat colon. PloS one. 2014; 9(5): e96004. doi: 10.1371/journal.pone.0096004
Suryati S, Husni E, Astuti W, Ranura N. Karakterisasi dan uji sitotoksik Daun Jeruju (Acanthus ilicifolius). Jurnal Sains Farmasi & Klinis. 2019; 5(3): 207-211. doi: 10.25077/jsfk.5.3.207-211.2018
Babu BH, Shylesh BS, Padikkala J. Tumour reducing and anticarcinogenic activity of Acanthus ilicifolius in mice. Journal of Ethnopharmacology. 2002; 79(1): 27-33. doi: 10.1016/S0378-8741(01)00347-6
Paul T, Ramasubbu S. The antioxidant, anticancer and anticoagulant activities of Acanthus ilicifolius. L. roots and Lumnitzera racemosa Willd. leaves, from southeast coast of India. Journal of Applied Pharmaceutical Science. 2017; 7(3): 081-087. doi:10.7324/JAPS.2017.70313
Rajamanickam E, Gurudeeban S, Satyavani K, Ramanathan T. Chemopreventive effect of Acanthus ilicifolius extract on modulating antioxidants, lipid peroxidation and membrane bound enzymes in diethyl nitrosamine induced liver carcinogenesis. International Journal of Cancer Research. 2016; 12: 1-6. doi: 10.3923/ijcr.2016.1.16
Nurmawati. Anticancer Activities of Extracts and Purified Compounds from Jeruju Putih (Acanthus Ilicifolius L.). 2002. Masters thesis, Universiti Putra Malaysia.
Venkataiah G, Ahmed MI, Reddy DS, Rejeena M. Anti-diabetic activity of Acanthus ilicifolius root extract in alloxan induced diabetic rats. Indo American Journal of Pharmaceutical Research.2013; 3(11): 9007-9012.
Widiastuti EL, Ardiansyah BK, Nurcahyani N, Silvinia A. Antidiabetic potency of jeruju (Acanthus ilicifolius. L.) ethanol extract and taurine on histopathological response of mice kidney (Mus musculus L.) induced by alloxan. Journal of Physics: Conference Series. 2021; 1751(1): 012052. doi: 10.1088/1742-6596/1751/1/012052
Gayatri, GA. Vitexin - A potential antidiabetic molecule isolated from mangrove plant Acanthus ilicifolius. Linn. Doctor of Philosophy. Thesis. 2018. Vellore Institute of Technology, India.
Batta AK, Xu G, Honda A, Miyazaki T, Salen G. Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat. Metabolism. 2006; 55(3): 292-299. doi: 10.1016/j.metabol.2005.08.024
Zhang Y, Shen J, Ma X, Yao M, Zhang Y, Cao D. Anti-infammatory and antioxidant activities of acteoside isolated from Acanthus ilicifolius var. xiamenensis. Applied Biological Chemistry. 2022; 65(29): 1-2. doi: 10.1186/s13765-022-00695-w
Manilal A, Sujith S, Kiran GS, Selvin J, Shakir C. Biopotentials of mangroves collected from the southwest coast of India. Global Journal of Biotechnology & Biochemistry. 2009; 4(1): 59-65.
Andriani D, Setianingtyas D. The Effect of Acanthus Ilicifolius Extract on Anticandida Albicans Antibody in Wistar Rats with Oral Candidiasis Immunosuppressed Model. DENTA Jurnal Kedokteran Gigi. 2017; 11(1): 35-42.
Andriani D, Pargaputri AF. Enhance of IL-22 expression in Oral Candidiasis Immunosupressed Model with Acanthus ilicifolius Extract Therapy. In IOP Conference Series: Earth and Environmental Science. 2019; 217: 012056. doi: 10.1088/1755-1315/217/1/012056
Andriani D, Pargaputri AF. The effects of Acanthus ilicifolius chloroform extract on TLR-2 expression of macrophages in oral candidiasis. Dental Journal. 2018; 51(4): 205-209. doi: 10.20473/j.djmkg.v51.i4.p205–209
Setyawan G, Andriani D, Soesilo D. The effect of granting Acanthus ilicifolius leaf topical methanol extracts to the amount of macrofags in healing of oral candidiasis models with immunosuppression condition. DENTA Jurnal Kedokteran Gigi. 2019; 13(1): 61-68.
Ganesh S, Vennila JJ. Screening for antimicrobial activity in Acanthus ilicifolius. Archives of Applied Science Research. 2010; 2(5): 311-315.
Asha KK, Mathew S, Lakshmanan PT. Flavonoids, and phenolic compounds in two mangrove species and their antioxidant property. Indian Journal of Marine Sciences. 2012; 41: 259-264.
Kumar KM, Gorain B, Roy DK, Samanta SK, Pal M, Biswas P, Roy A, Adhikari D, Karmakar S, Sen T. Anti-inflammatory activity of Acanthus ilicifolius. Journal of Ethnopharmacology. 2008; 120(1): 7-12. doi: 10.1016/j.jep.2008.07.024
Karim R, Begum MM, Alim MA, Uddin MS, Kabir MT, Khan AF, Islam T, Khan SI, Rahman MS. Effects of Alcoholic Extracts of Bangladeshi Mangrove Acanthus ilicifolius. Linn. (Acanthaceae) Leaf and Stem on Atherogenic Model of Wistar Albino Rats. Evidence-Based Complementary and Alternative Medicine. 2021; 7539037. doi: 10.1155/2021/7539037
Biswas R, Rahman SM, Islam KM, Billah M, Aunjum A, Nurunnabi TR, Kundu SK, Islam M. Antioxidant, Anti-inflammatory, and Anticoagulation Properties of Aegiceras corniculatum and Acanthus ilicifolius. Pharmaceutical and Biomedical Research. 2019; 10;5(3):35-44. doi: 10.18502/pbr.v5i3.2117
Nizamuddin BS, Suresh C, Danamma B, Dada M, Maajid A. Evaluation of antiulcer activity in the methanol extract of Acanthus ilicifolius leaves in experimental rats. International Journal of Pharmacy and Industrial Research. 2011; 1: 57-62.
Islam MA, Saifuzzaman M, Ahmed F, Rahman MM, Sultana NA, Naher K. Antinociceptive activity of methanolic extract of Acanthus ilicifolius Linn leaves. Turkish Journal of Pharmaceutical Science. 2012; 9(1): 51-60.
Liu L, Fan H, Qi P, Mei Y, Zhou L, Cai L, Lin X, Lin J. Synthesis and hepatoprotective properties of Acanthus ilicifolius alkaloid A and its derivatives. Experimental and Therapeutic Medicine. 2013; 6(3): 796-802. doi: 10.3892/etm.2013.1189
Babu S, Jayaraman S. An update on β-sitosterol: A potential herbal nutraceutical for diabetic management. Biomedicine & Pharmacotherapy. 2020; 131: 110702. doi: 10.1016/j.biopha.2020.110702
Son J, Lee SY. Therapeutic potential of ursonic acid: comparison with ursolic acid. Biomolecules. 2020; 10(11): 1505. doi: 10.3390/biom10111505
Wei PH, Wu SZ, Mu XM, Xu B, Su QJ, Wei JL, Yang Y, Qin B, Xie ZC. Effect of alcohol extract of Acanthus ilicifolius. L. on anti-duck hepatitis B virus and protection of liver. Journal of Ethnopharmacology. 2015; 160: 1-5. doi: 10.1016/j.jep.2014.10.050
Husori DI, Tarigan H, Gemasih S, Ningsih SR. In vitro anthelmintic activity of Acanthus ilicifolius leaves extracts on Ascaridia galli and Pheretima posthuma. Journal of Applied Pharmaceutical Science. 2018; 8(2): 164-167. doi: 10.7324/JAPS.2018.8224
Gustiani H. Formulation and Test Activities of Antidandruff Sample of Leaves Ethanol Extract (Acanthus ilicifolius) of Pityrosporum ovale. Indonesian Journal of Pharma Science. 2019; 1(1): 36-47.
Ahmed K, Roy BK, Saha BK. Pharmacological evaluation of Acanthus ilicifolius L. root extract for asthmatic condition. Bangladesh Journal of Scientific and Industrial Research. 2005; 40: 195-202.