Outcome of Co-administration of Clomiphene Citrate in Gonadotropins Stimulated In vitro Fertilisation Cycles
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Abstract
Introduction: Co-administration of clomiphene citrate during the early phase in in vitro fertilisation (IVF) cycles has been used by clinicians for several years to improve outcomes. Materials and methods: This is a single centre retrospective study involving 222 patients with 81 patients underwent IVF using co-administration of Clomiphene Citrate (CC) with gonadotropins (study group - group A) and 141 patients used only gonadotropins (control group - group B) were compared. The outcome data of the IVF cycles were focused on four major aspects of which are the total gonadotropin usage, number of oocytes obtained, fertilisation rate and top-quality embryos produced. Results: The Mean ± Standard Deviation (SD) of patients age is (34.72 ± 3.25) and (34.39 ± 3.39) years old from group A and B respectively. Mean ± (SD) of total usage of gonadotropins (1834.57 ± 477.34iu) vs (2645.04 ± 669.66iu), (p< 0.0001), mean number of oocytes ± (SD) retrieved (8.54 ± 5.95) vs (10.32 ± 6.67 ), (p = 0.048), mean ± (SD) fertilisation rate (39.82 ± 30.46) vs (49.04 ± 27.62), (p=0.027) and mean percentage ± (SD) of the top-quality embryos are (17.96 ± 25.68) vs (28.02 ± 32.19), (p=0.02) from group A and B respectively. Conclusion: Co-administration of CC with gonadotropins in IVF reduces the total amount of gonadotropins required in the IVF cycle however it also reduces the number of oocytes retrieved, fertilization rate and top quality embryos.
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