Mucinous Ovarian Cancer: A Review of Diagnosis and Treatment
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Abstract
Mucinous ovarian cancer (MOC) is a rare pathological type of ovarian epithelial cancer. Clinical treatment mostly refers to the relevant guidelines for serous ovarian cancer (SOC). However, due to the clinical symptoms of MOC, the physical characteristics and molecular biology characteristics are significantly different from SOC, necessitating careful differentiation in diagnosis and treatment. Surgery combined with adjuvant chemotherapy is the current standard treatment for MOC. However, due to its low prevalence, clinical trials are difficult to conduct, evidence-based medicine is lacking, and there is a lack of consensus on the indications for intraoperative appendectomy and the selection of postoperative adjuvant chemotherapy regimens. In addition, preclinical research on targeted therapy and immunotherapy needs further development to facilitate accurate diagnosis and personalized treatment of MOC.
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Craig O, Salazar C, Gorringe KL. Options for the treatment of mucinous ovarian carcinoma. Curr Treat Options Oncol .2021;22(12):114. Available from: DOI: 10.1007/s11864-021-00904-6
Osullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, et al. Risk factors for early-onset colorectal cancer: a systematic review and meta-analysis. Clinical gastroenterology and hepatology. 2022;20:1229–40. DOI: 10.1016/j.cgh.2021.01.037
Watts GF, Sullivan DR, Poplawski N, van Bockxmeer F, Hamilton-Craig I, Clifton PM, et al. Familial hypercholesterolaemia: a model of care for Australasia. Atheroscler Suppl .2011;12(2):221–63. DOI:10.1016/j.atherosclerosissup.2011.06.001
Gorringe KL, Cheasley D, Wakefield MJ, Ryland GL, Allan PE, Alsop K, et al. Therapeutic options for mucinous ovarian carcinoma. Gynecol Oncol .2020;156(3):552–60. DOI: 10.1016/j.ygyno.2019.12.015
Simons M, Massuger L, Bruls J, Bulten J, Teerenstra S, Nagtegaal I. Relatively poor survival of mucinous ovarian carcinoma in advanced stage: A systematic review and meta-analysis: A systematic review and meta-analysis. Int J Gynecol Cancer .2017;27(4):651–8. DOI: 10.1097/igc.0000000000000932
Aytekin O, Yüksel D, Oktar O, Çakır C, Kimyon Cömert G, Korkmaz V, et al. The surgical and clinicopathological characteristics of primary mucinous ovarian cancer: a single institution 30-year retrospective analysis. J Turk Ger Gynecol Assoc .2023;24(4):252–60. DOI: 10.4274/jtgga.galenos.2023.2022-8-1
Al-Hussaniy H, Sameer AH, Oraibi HN. The relationship between statin therapy and adipocytokine/inflammatory mediators in dyslipidemic nondiabetic patients: A comparative study. Pharmacia. 2023;70:581–5. DOI: 10.3897/pharmacia.70.e109800
Canlorbe G, Chabbert-Buffet N, Uzan C. Fertility-sparing surgery for ovarian cancer. J Clin Med .2021;10(18):4235. DOI: 10.3390/jcm10184235
Schuurman T, Zilver S, Samuels S, Schats W, Amant F, van Trommel N, et al. Fertility-sparing surgery in gynecologic cancer: A systematic review. Cancers (Basel) .2021;13(5). DOI: 10.3390/cancers13051008
Borella F, Mitidieri M, Cosma S, Benedetto C, Bertero L, Fucina S, et al. Update on prognostic and predictive markers in mucinous ovarian cancer. Cancers (Basel) .2023;15(4). DOI: 10.3390/cancers15041172
Al-Hussaniy H, Al-Biati H. The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis. Medical and Pharmaceutical Journal. 2022;1(2):52–63. DOI: 10.55940/medphar20227
Shrestha BM, Shrestha S, Kharel S, Aryal S, Rauniyar R, Kuikel S, et al. Giant ovarian mucinous cystadenocarcinoma: A case report. Clin Case Rep .2022;10(7):e6067. DOI: 10.1002/ccr3.6067
Flores-Balcázar CH, Urías-Arce DM. Radiotherapy in women with epithelial ovarian cancer: historical role, current advances, and indications. Chin Clin Oncol .2020;9(4):49. DOI: 10.21037/cco-20-10
Al-Hussaniy HA, Hassan AF, Oraibi AI, Al-Juhaishi AM, Naji FA, Al-Tameemi ZS. Clinical Pharmacogenetics of Angiotensin II Receptor Blockers in Iraq. Journal of Pharmacy and Bioallied Sciences. 2023;15(3):101-6. DOI: 10.4103/jpbs.jpbs_313_23
Luo C, Cen S, Ding G, Wu W. Mucinous colorectal adenocarcinoma: clinical pathology and treatment options. Cancer Commun (Lond) .2019;39(1):13. DOI: 10.1186/s40880-019-0361-0
Stimpson S, Powers J, Clarno K, Pawlowski R, Gardner R, Novascone S, et al. Pellet-clad mechanical interaction screening using VERA applied to Watts Bar Unit 1, Cycles 1-3. Nuclear Engineering and Design. 2018;327:172–86.
Tee WL, Robinson F, Avoi R, Dhanaraj P, Kaur N, Sanudin NH. Ethnicity and Dietary Practices as Colorectal Cancer Risk Predictors: A Retrospective Case-control Study in Sabah, Malaysia. Malaysian Journal of Medicine & Health Sciences. 2023 ; (SUPP20)19: 72-87
Zhang Y-Y, Xue S, Wang Z-M, Jin M-S, Chen Z-P, Chen G, et al. Thyroid metastasis from breast cancer presenting with enlarged lateral cervical lymph nodes: A case report. World J Clin Cases .2020;8(4):838–47. Available from: http://dx.doi.org/10.12998/wjcc.v8.i4.838
Shaaban SM, Gaber Z, Semary S, Dewidar AM. Impact of Vitamin B12 on Outcome of Early Stage Luminal A and B Breast Cancer, single center experience. Medical and Pharmaceutical Journal. 2023;2(1):17–27.
Awad MM, Elsahar MI. Asymptomatic Bacterial Infection in Pregnancy: A new update. Med Pharm J .2022;1(2):1–11. Available from: http://dx.doi.org/10.55940/medphar20228
Beshna E, Ashour RA, Layas NA, Eldawi NS. Pharmacovigilance knowledge, attitudes, and practices of pharmacists in Zawia (Libya). Medical and Pharmaceutical Journal. 2023;2(2):99–106.
Al-Hussaniy HA, Alburghaif AH, Alkhafaje Z, Al-Zobaidy MA-HJ, Alkuraishy HM, Mostafa-Hedeab G, et al. Chemotherapy-induced cardiotoxicity: a new perspective on the role of Digoxin, ATG7 activators, Resveratrol, and herbal drugs. J Med Life .2023;16(4):491–500. Available from: http://dx.doi.org/10.25122/jml-2022-0322
Al-Hussaniy H, Al-Tameemi Z, Al-Zubaidi B, Oraibi A, Naji F. Pharmacological properties of Spirulina species: Hepatoprotective, antioxidant and anticancer effects. Farmacia. 2023;71(4):670–8.
Hussein ZR, Omar SK, Alkazraji RAM, Alsamarrai AN, Alrubaye HS, Al-Hussaniy HA. Efficacy of Aflibercept as initial treatment for neovascular age-related macular degeneration in an Iraqi patient sample. J Med Life .2023;16(2):235–43. Available from: http://dx.doi.org/10.25122/jml-2022-0356
Al-Hassany H, Albu-Rghaif AH, Naji M. Tumor diagnosis by genetic markers protein P-53, p16, C-MYC, N-MYC, protein K-Ras, and gene her-2 Neu is this possible. Pakistan Journal of Medical and Health Sciences. 2021;15(8):2350–4.
Altalebi RR, Al-Hussaniy HA, Al-Tameemi ZS, Al-Zobaidy MA-H, Albu-Rghaif AH, Alkuraishy HM, et al. Non-alcoholic fatty liver disease: relation to juvenile obesity, lipid profile, and hepatic enzymes. J Med Life .2023;16(1):42–7. Available from: http://dx.doi.org/10.25122/jml-2022-0091
Salim Mahmood A, Ammoo AM, Ali MHM, Hameed TM, Al-Hussaniy HA, Aljumaili AAA, et al. Antiepileptic effect of neuroaid® on strychnine-induced convulsions in mice. Pharmaceuticals (Basel) .2022;15(12):1468. Available from: http://dx.doi.org/10.3390/ph15121468
Ahmed MS, Reyadh AR, Shareef BQ, Ali AR, Hany AH, Meena AN. Increasing Prevalence of Congenital Hypothyroidism in children with Down Syndrome who have a family history of Thyroid disease. Research Journal of Pharmacy and Technology. 2023;16(3):1327–32.
Al-Kuraishy HM, Al-Gareeb AI, Al-Hussaniy HA, Al-Harcan NAH, Alexiou A, Batiha GE-S. Neutrophil Extracellular Traps (NETs) and Covid-19: A new frontiers for therapeutic modality. Int Immunopharmacol .2022;104(108516):108516. Available from: http://dx.doi.org/10.1016/j.intimp.2021.108516
Gasmi M, Rahma Z, Williams-Hooker RW, Sharma A. Research Article Production and Characterization of Recombinant Multi-Epitope G Glycoprotein of Rabies Virus. Medical and Pharmaceutical Journal. 2023;2(3):134–48.
Euscher ED, Buza N, Immunohistochemistry HP. Practical Gynecologic Pathology: Frequently Asked Questions. 2021:367–416.
Terada T. An immunohistochemical study of primary signet-ring cell carcinoma of the stomach and colorectum: III. Expressions of EMA, CEA, CA19-9, CDX-2, p53, Ki-67 antigen, TTF-1, vimentin, and p63 in normal mucosa and in 42 cases. Int J Clin Exp Pathol. 2013;6(4):630–8.
Shaik MA, Tham HW. Emerging Role of Galectins as Molecular Targets for Cancer Therapy: A Review. Malaysian Journal of Medicine & Health Sciences. 2023 ;19(5): 378 - 388.
Reid BM, Permuth JB, Sellers TA. Epidemiology of ovarian cancer: a review. Cancer Biol Med .2017;14(1):9–32. Available from: http://dx.doi.org/10.20892/j.issn.2095-3941.2016.0084
Simons M, Bolhuis T, De Haan AF, Bruggink AH, Bulten J, Massuger LF, et al. A novel algorithm for better distinction of primary mucinous ovarian carcinomas and mucinous carcinomas metastatic to the ovary. Virchows Arch .2019;474(3):289–96. Available from: http://dx.doi.org/10.1007/s00428-018-2504-0
Hou Z-H, Lu B, Gao Y, Cao H-L, Yu F-F, Jing N, et al. Matrix metalloproteinase-9 (MMP-9) and myeloperoxidase (MPO) levels in patients with nonobstructive coronary artery disease detected by coronary computed tomographic angiography. Acad Radiol .2013;20(1):25–31. Available from: http://dx.doi.org/10.1016/j.acra.2012.07.014
Bacalbasa N, Balescu I, Vilcu M, Dima S, Diaconu C, Iliescu L, et al. The risk of para-aortic lymph node metastases in apparent early stage ovarian cancer. Medicina (Kaunas) .2020;56(3):108. Available from: http://dx.doi.org/10.3390/medicina56030108
Matsuo K, Ahn EH, Prather CP, Eno ML, Im DD, Rosenshein NB. Patient-reported symptoms and survival in ovarian cancer. Int J Gynecol Cancer .2011;21(9):1555–65. Available from: http://dx.doi.org/10.1097/igc.0b013e3182259c7f
Babaier A, Ghatage P. Mucinous cancer of the ovary: overview and current status. Diagnostics. 2020 Jan, 10(1):52. A, Ghatage P. Mucinous cancer of the ovary: Overview and current status. Diagnostics (Basel) .2020;10(1):52. Available from: http://dx.doi.org/10.3390/diagnostics10010052
Latincic S, Pavlov M, Vasiljevic J, Vasin D, Dimic-Cumic M, Micev M, et al. Extreme leukocytosis and gangrenous cholecystitis associated with cytoreductive surgery and HIPEC-treated mucinos ovary cancer: Case report and literature review. Clin Pract .2023;13(5):1137–45. Available from: http://dx.doi.org/10.3390/clinpract13050102
Gradishar WJ, Moran MS, Abraham J, Aft R, Allison AD, Blair KH, et al. NCCN guidelines® insights: Breast cancer, version 4.2021: Featured updates to the NCCN guidelines. Journal of the National Comprehensive Cancer Network. 2021;19:484–93.
Sugai S, Yamawaki K, Sekizuka T, Haino K, Yoshihara K, Nishijima K. Pathologically diagnosed placenta accreta spectrum without placenta previa: a systematic review and meta-analysis. Am J Obstet Gynecol MFM .2023;5(8):101027. Available from: http://dx.doi.org/10.1016/j.ajogmf.2023.101027
Zhang K, Feng S, Ge Y, Ding B, Shen Y. A nomogram based on SEER database for predicting prognosis in patients with mucinous ovarian cancer: A real-world study. Int J Womens Health .2022;14:931–43. Available from: http://dx.doi.org/10.2147/IJWH.S372328
Donnez O, Darmon JC, Troyer D, Sterkers J. Fertility-Saving Surgery for Gynecological Cancers. Fertility Preservation: Principles and Practice. 2021.
Rosendahl M, Haueberg Oester LA, Høgdall CK. The importance of appendectomy in surgery for mucinous adenocarcinoma of the ovary. Int J Gynecol Cancer .2017;27(3):430–6. Available from: http://dx.doi.org/10.1097/igc.0000000000000910
Lin JE, Seo S, Kushner DM, Rose SL. The role of appendectomy for mucinous ovarian neoplasms. Am J Obstet Gynecol .2013;208(1):46.e1-46.e4. Available from: http://dx.doi.org/10.1016/j.ajog.2012.10.863
Mohammed M, Adnan AA. In-silico design, molecular docking, molecular dynamic simulations, Molecular mechanics with generalised Born and surface area solvation study, and pharmacokinetic prediction of novel diclofenac as anti-inflammatory compounds. Turkish Computational and Theoretical Chemistry. 2024; 8(3):108-21.
Hoehn RS, Rieser CJ, Choudry MH, Melnitchouk N, Hechtman J, Bahary N. Current management of appendiceal neoplasms. Am Soc Clin Oncol Educ Book .2021;41(41):1–15. Available from: http://dx.doi.org/10.1200/EDBK_321009
Tippegowda SB. A Case Study on Ovarian Cancer-Palliative Perspective. Asian J Nurs Educ Res .2015;5(3):446. Available from: http://dx.doi.org/10.5958/2349-2996.2015.00090.7
Ahmad W, Jawed R, Khan I, Khallel R, Hakam D. A review on poly (ADP-ribose) polymerase (PARP)-An enzyme that share the ability to catalyze the transfer of ADP-ribose to target proteins. Asian Journal of Pharmacy and Technology. 2023;13(3):223–8.
Barua A, Kesavan K, Jayanthi S. Molecular docking studies of plant compounds to identify efficient inhibitors for ovarian cancer. Res J Pharm Technol .2018;11(9):3811. Available from: http://dx.doi.org/10.5958/0974-360x.2018.00698.4
Sagheer O.M., Ahmed MS, Jwaid MM, Al-Hussaniy HA, Al-Tameemi ZS. The development of molecular docking and molecular dynamics and their application in the field of chemistry and computer simulation. J Med Pharm Allied Sci. 2023;12:5552-62.
Al-Hussaniy HA. The Effect of MicroRNA-409-3p for Treatment and Response to Tumor Proliferation of Lung Cancer Cell Lines (In Vitro). Asian Pacific Journal of Cancer Prevention. 2022; 23(9):3151–6.
Nasioudis D, Haggerty AF, Giuntoli RL 2nd, Burger RA, Morgan MA, Ko EM, et al. Adjuvant chemotherapy is not associated with a survival benefit for patients with early stage mucinous ovarian carcinoma. Gynecol Oncol .2019;154(2):302–7. DOI:10.1016/j.ygyno.2019.05.009
Ledermann JA, Luvero D, Shafer A, O’Connor D, Mangili G, Friedlander M, et al. Gynecologic cancer InterGroup (GCIG) consensus review for mucinous ovarian carcinoma. Int J Gynecol Cancer .2014;24(Supp 3):S14–9. DOI: 10.1097/igc.0000000000000296
Marin JJG, Macias RIR, Monte MJ, Herraez E, Peleteiro-Vigil A, Blas BS de, et al. Cellular mechanisms accounting for the refractoriness of colorectal carcinoma to pharmacological treatment. Cancers (Basel) .2020; 12(9). DOI:10.3390/cancers12092605
Jwaid MM, Alwan MJ, Ihsan I, Jwaid MM, Muhsin YF, Al-hussaniy HA. Novel anticoagulants in the management of atrial fibrillation: A comprehensive comparative analysis. Pharmacia. 2024; 71:1-6. DOI 10.3897/pharmacia.71.e113097
Bakrin N, Bereder JM, Decullier E, Classe JM, Msika S, Lorimier G, et al. Peritoneal carcinomatosis treated with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma: a French multicentre retrospective cohort study of 566 patients. Eur J Surg Oncol .2013;39(12):1435–43. DOI: 10.1016/j.ejso.2013.09.030
Yap DRY, Wong JSM, Tan QX, Tan JW-S, Chia CS, Ong C-AJ. Effect of HIPEC on peritoneal recurrence in peritoneal metastasis treated with cytoreductive surgery: A systematic review. Front Oncol .2021; 11:795390. DOI: 10.3389/fonc.2021.795390
Veneziani AC, Gonzalez-Ochoa E, Alqaisi H, Madariaga A, Bhat G, Rouzbahman M, et al. Heterogeneity and treatment landscape of ovarian carcinoma. Nat Rev Clin Oncol .2023; DOI: 10.1038/s41571-023-00819-1
Gallotta V, Certelli C, Oliva R, Rosati A, Federico A, Loverro M, et al. Robotic surgery in ovarian cancer. Best Pract Res Clin Obstet Gynaecol .2023;90(102391):102391. DOI: 10.1016/j.bpobgyn.2023.102391
Xia L, Ma W, Afrashteh A, Sajadi MA, Fakheri H, Valilo M. The nuclear factor erythroid 2-related factor 2/p53 axis in breast cancer. Biochem Med (Zagreb) .2023;33(3):030504. DOI: 10.11613/BM.2023.030504
Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, et al. Epigenetic therapy for ovarian cancer: promise and progress. Clin Epigenetics .2019;11(1):7. DOI: 10.1186/s13148-018-0602-0
Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, et al. Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for preclinical evaluation of novel therapeutics. Clin Cancer Res .2017;23(5):1263–73. DOI: 10.1158/1078-0432.CCR-16-1237
Anvari K, Shahabadi M, Welsh JS, Javadinia SA, Zarei E. Outcome of second line treatment of recurrent high-grade glioma by re-irradiation or bevacizumab-based chemotherapy: A cross sectional study. Asian Pacific Journal of Cancer Prevention. 2023; 24(5):1507.
Aleissa MS, Al-Zharani M, Alneghery LM, Aleissa AM. Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3). Saudi Pharm J .2023;31(1):110–8. DOI: 10.1016/j.jsps.2022.11.009
Al-Hammadi N, AlSabri E, Kudhair AH, Qassam H, Hadi NR. Coq10 for preventing cardiotoxicity in breast cancer patients treated with trastuzumab. Journal of Medicine and Life. 2023; 16(8):1188.
Al-Hussaniy HA, Al-Zobaidy MJ. Effects of Mdm2 Inhibitors on Cellular Viability of Breast Cancer Cell Lines HP100, MCF7. bratislava medical journal. 2024; 125(10):627–34.
Abu Hajleh MN, AL-Samydai A, Al-Dujaili EA. Nano, micro particulate and cosmetic delivery systems of polylactic acid: A mini review. Journal of Cosmetic Dermatology. 2020; 19(11):2805-11.
Zaanan A, Shi Q, Taieb J, Alberts SR, Meyers JP, Smyrk TC, et al. Role of deficient DNA mismatch repair status in patients with stage III colon cancer treated with FOLFOX adjuvant chemotherapy: A pooled analysis from 2 randomized clinical trials. JAMA Oncol .2018;4(3):379–83. DOI:10.1001/jamaoncol.2017.2899
Lee JS, Ruppin E. Multiomics prediction of response rates to therapies to inhibit programmed cell death 1 and programmed cell death 1 ligand 1. JAMA Oncol .2019;5(11):1614–8. DOI:10.1001/jamaoncol.2019.2311
Al‐Halaseh LK, Al-Adaileh S, Mbaideen A, Hajleh MN, Al-Samydai A, Zakaraya ZZ, Dayyih WA. Implication of parabens in cosmetics and cosmeceuticals: Advantages and limitations. Journal of Cosmetic Dermatology. 2022 Aug;21(8):3265-71.
Judd NP, Allen CT, Winkler AE, Uppaluri R. Comparative analysis of tumor-infiltrating lymphocytes in a syngeneic mouse model of oral cancer. Otolaryngol Head Neck Surg .2012;147(3):493–500. DOI:10.1177/0194599812442037
Haki M, Al-Biati HA, Al-Tameemi ZS, Ali IS, Al-Hussaniy HA. Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment. Medicine. 2024 ;103(8):e37297.
Al-Samydai A, Al-Mamoori F, Abdelnabi H, Aburjai T. An updated review on anticancer activity of capsaicin. Interational Journal of Scientific and Technology Research. 2019;8(12):2625-30.