Association of Vitamin D Receptor Gene BsmI (rs1544410) Polymorphism with Bone Speed of Sound, Serum Vitamin D Concentration and Isokinetic Muscular Performance in Malay Teenage Females
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Abstract
Introduction: This study was carried out to examine the association of Vitamin D receptor (VDR) gene BsmI (rs1544410) polymorphism with bone speed of sound, serum vitamin D concentration, and muscular peak torque and power in teenage female athletes and non-athletes of Malay origin. Materials and methods: Sixty young female athletes and non-athletes were recruited. DNA was extracted and genotyping of VDR gene BsmI polymorphism was performed. Bone speed of sound (SOS), serum vitamin D concentration, and muscular peak torque and power were measured. Results: Athletes with bb genotype had significantly greater bone SOS in the arm, while those with Bb genotype had significantly greater bone SOS in the leg compared to BB genotype. Non-athletes with BB genotype had significantly higher flexion peak torque per body weight and isokinetic extension in the leg compared to Bb genotype. Non-athletes with BB and Bb genotype exhibited significantly higher arm isokinetic flexion peak torque compared to bb genotype. No significant associations were observed between BsmI genotypes and serum vitamin D concentration. Conclusion: VDR BsmI bb and Bb genotypes may be associated with better bone health status in Malay teenage female athletes. VDR BsmI BB and Bb genotypes may be associated with higher muscular strength in Malay teenage female non-athletes.
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