Antioxidant Effects of Tocotrienol-rich Fractions Supplementation on Obesity-induced Oxidative Stress in Female Reproductive System: A Systematic Review
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Abstract
Introduction: This review summarizes the antioxidant effects of tocotrienol-rich fractions (TRF) supplementation on obesity-induced oxidative stress (OS) in female reproductive system. Design: Systematic review. Data sources: PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar. Materials and methods: The authors conducted an electronic search of articles published from 2014 to 2024 on the effects of TRF supplementation on obesity-induced OS in the female reproductive system via several databases. Data were gathered from indexed articles, research papers, case studies, and experimental studies. Risk of bias was performed using standardised tools such as the Cochrane Risk of Bias Tool and the Newcastle-Ottawa Scale. Results: 25 studies investigated the benefit of TRF on the maternal obesity-induced OS in human studies and animal model. From the 25 studies, 9 studies demonstrated the benefits of TRF supplementation in reducing OS biomarkers in maternal obese models. Likewise, 16 of the 25 studies reported the benefits of TRF supplementation in improving reproductive health, whereas 15 of the 25 studies demonstrated the mechanism of action of TRF supplementation in scavenging the radicals and preventing oxidative damage and lipid peroxidation in maternal obese models. Conclusion: TRF supplementation significantly reduced the OS biomarkers by scavenging the radicals, which inhibit lipid peroxidation and oxidative damage mechanisms, thus improving female reproductive health outcomes in maternal obese models. Hence, this systematic review provides significant evidence supporting the benefit of TRF supplementation in obesity-induced OS in female reproductive system.
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