Exploring the Impact of Subchorionic Hematoma on Pregnancies in Women With Recurrent Pregnancy Loss Experiences
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Abstract
Purpose: This prospective study aimed to evaluate the impact of subchorionic hematoma (SCH) on pregnancy outcomes in women with recurrent pregnancy loss (RPL) and to explore the relationship between SCH, thrombophilia, and low-dose aspirin (LDA) use. SCH characteristics such as size and location were inconsistently recorded and thus excluded from the final analysis. Patients and Methods: A case-control study was conducted between May 1, 2009, and June 30, 2017, at Mosul Teaching Hospitals. A total of 274 women with a history of RPL were enrolled, of whom 31 were diagnosed with SCH during early pregnancy and monitored with serial ultrasounds alongside standard miscarriage management. Demographic and clinical data were collected, and pregnancy outcomes were compared between women with and without SCH. A subgroup analysis assessed the impact of continued LDA use on SCH duration and pregnancy outcomes. Univariable and multivariable analyses were used to control for confounding variables. Results: SCH was significantly associated with thrombophilia (61.3% vs. 29.6%, p = 0.041), suggesting a potential link between hypercoagulability and SCH formation. No significant differences were found between the SCH and non-SCH groups regarding maternal age, BMI, parity, or RPL etiology. Live birth rates (70.9% vs. 81.2%, p = 0.209) and miscarriage rates (25.8% vs. 15.6%, p = 0.209) were similar. LDA use did not significantly affect live birth rates, SCH duration, or resolution. Conclusion: SCH does not significantly impact pregnancy outcomes in RPL. Thrombophilia may contribute to SCH formation, but continued LDA use appears to have no effect on outcomes.
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