Combination treatment of Umbilical Cord-derived Mesenchymal Stem Cell (UC-MSC) and Umbilical Cord Mesenchymal Stem Cell-derived Conditioned Medium (UCMSC-CM) for Keloid Post Chronic Burn Injury: A Case Report

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Published: Mar 6, 2024
Keywords:
Keloid, Mesenchymal stem cells, Conditioned medium, Chronic burn injury

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Qori Haly
Jakarta Life Sciences and Aesthetics Clinic, Rukan Permata Blok E No. 31, 12210 East Grogol, Kebayoran Lama, South Jakarta, Indonesia
Cynthia R Sartika
PT. Prodia StemCell Indonesia, Kramat ViI No. 11, 10430 Senen, Central Jakarta, Indonesia
Rima Haifa
PT. Prodia StemCell Indonesia, Kramat ViI No. 11, 10430 Senen, Central Jakarta, Indonesia
Nadya Karina
PT. Prodia StemCell Indonesia, Kramat ViI No. 11, 10430 Senen, Central Jakarta, Indonesia
Viana Rahmawati
PT. Prodia StemCell Indonesia, Kramat ViI No. 11, 10430 Senen, Central Jakarta, Indonesia
Nabilla F Naura
PT. Prodia StemCell Indonesia, Kramat ViI No. 11, 10430 Senen, Central Jakarta, Indonesia

Abstract

A 44-years-old woman with hard and thick keloids after chronic mercury burn injury underwent a several times of reconstructive surgery. The patient had excised surgery and injected Umbilical Cord-derived Mesenchymal Stem Cells (UC-MSCs) and Umbilical Cord Mesenchymal Stem Cells-derived Condtioned Medium (UCMSC-CM) 9 times within 9 months. Seven times injection of UC-MSCs of 5x106 cells and UCMSC-CM of 20 cc 2 times at months 4 and 9. The results of this therapy showed gradual improvement without any side effects and the size of the keloid reduced from 25x16 cm to 23x14 cm after 9 months. Keloid thickness from 12 mm to 4 mm. Keloid color becomes lighter and skin texture is more supple and soft. The cases showed that UC-MSCs and UCMSC-CM can be a potential treatment for keloids after chronic burn either alone or in combination with surgery.

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How to Cite
Haly, Q., Sartika, C. R., Haifa, R., Karina, N., Rahmawati, V., & Naura, N. F. (2024). Combination treatment of Umbilical Cord-derived Mesenchymal Stem Cell (UC-MSC) and Umbilical Cord Mesenchymal Stem Cell-derived Conditioned Medium (UCMSC-CM) for Keloid Post Chronic Burn Injury: A Case Report. Malaysian Journal of Medicine and Health Sciences, 18(1), 353–355. Retrieved from http://mjmhsojs.upm.edu.my/index.php/mjmhs/article/view/284
Issue
Vol. 18 No. 1 (2022)
Section
Case Report

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Figure 2: Patient after 7 times of stem cell and 2 times of secretome injections

Figure 1: Patient after 4 times of stem cell injections

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