Genetic Analysis of a Young Adult Presented with Acute Myocardial Infarction with No Traditional Risk Factors: A Novel Case Report

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Published: Mar 6, 2024
Keywords:
Young onset myocardial infarction, ST-elevation, Infinium Asian Screening Array, Preventive and personalised medicine

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Huzairi Sani
Cardiology unit, Internal Medicine department, Faculty of Medicine, Universiti Teknologi MARA Sungai Buloh 47000, Selangor, Malaysia.
Lay Kek Teh
Integrative Pharmacogenomics Institute (iPROMISE),UiTM Puncak Alam Campus, Bandar Puncak Alam, 42300 Puncak Alam, Selangor, Malaysia.
Mohd Nur Fakhruzzaman Noorizhab
Integrative Pharmacogenomics Institute (iPROMISE),UiTM Puncak Alam Campus, Bandar Puncak Alam, 42300 Puncak Alam, Selangor, Malaysia.
Mohd Zaki Salleh
Integrative Pharmacogenomics Institute (iPROMISE),UiTM Puncak Alam Campus, Bandar Puncak Alam, 42300 Puncak Alam, Selangor, Malaysia.
Sazzli Shahlan Kasim
Cardiology unit, Internal Medicine department, Faculty of Medicine, Universiti Teknologi MARA Sungai Buloh 47000, Selangor, Malaysia.

Abstract

Myocardial infarction (MI) in the young adults are more common among the Asians compared to the Caucasians. It is of great interest to investigate the genetic risks that increase the susceptibility of MI in young patients with no family history. We conducted a genetic analysis on a young adult diagnosed with acute MI. The coronary angiogram showed acute complete occlusion of the left anterior descending artery with 40% left ventricular ejection fraction (LVEF). Patient’s DNA was subjected to genotyping using Infinium Asian Screening Array. The genotypes were annotated and associated with risks of cardiovascular diseases catalogued in GWAS database. Ninety-four genetic variants were detected. Patient has more than half of the genetic variants being homozygous risk genotypes for coronary artery and coronary heart diseases. Identifying the potential genetic modifiers associated with MI in young patients is of great interest to help the clinician make informed decisions to implement preventive and personalised medicine for this patient.

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How to Cite
Sani, H., Teh, L. K., Noorizhab, M. N. F., Salleh, M. Z., & Kasim, S. S. (2024). Genetic Analysis of a Young Adult Presented with Acute Myocardial Infarction with No Traditional Risk Factors: A Novel Case Report. Malaysian Journal of Medicine and Health Sciences, 18(1), 349–352. Retrieved from http://mjmhsojs.upm.edu.my/index.php/mjmhs/article/view/294
Issue
Vol. 18 No. 1 (2022)
Section
Case Report

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