Case Series on Drug Reaction with Eosinophilia and Systemic Syndrome (DRESS) with Different Ocular Manifestation

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Published: Apr 30, 2021
Keywords:
SCAR, DRESS, corneal perforation, MGD

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Josephine En Hui Lee
Department of Ophthalmology, Hospital Raja Permaisuri Bainun, 30450 Ipoh, Perak, Malaysia
Kursiah Mohd Razali
Department of Ophthalmology, Hospital Raja Permaisuri Bainun, 30450 Ipoh, Perak, Malaysia
Adil Hussein
Department of Ophthalmology and Visual Sciences, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia

Abstract

“Drug reaction with eosinophilia and systemic syndrome” (DRESS) is a rare type of “severe cutaneous adverse re- action” (SCAR). We report 3 patients with DRESS who had different presentations. The first case developed DRESS following initiation of Allopurinol a month earlier. He presented with bilateral pseudomembranous conjunctivitis which resolved after 2 weeks. Two months later he presented with bilateral severe meibomian gland dysfunction (MGD), ocular surface disease (OSD) with severe dry eyes and left eye corneal perforation. The second case devel- oped DRESS following initiation of allopurinol and had bilateral conjunctivitis. As for the third case, DRESS hap- pened after taking Roxithromycin. She was diagnosed to have bilateral MGD, blepharitis and dry eyes. Case 2 and 3 did not develop ocular long-term complications. DRESS can cause acute and long-term ocular complications and therefore, following up patients with DRESS is essential to treat any complications with the aim to prevent corneal perforation.

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How to Cite
Lee, J. E. H., Mohd Razali, K., & Hussein, A. (2021). Case Series on Drug Reaction with Eosinophilia and Systemic Syndrome (DRESS) with Different Ocular Manifestation. Malaysian Journal of Medicine and Health Sciences, 17(2), 294–297. Retrieved from http://mjmhsojs.upm.edu.my/index.php/mjmhs/article/view/368
Issue
Vol. 17 No. 2 (2021)
Section
Case Series

References

Cho Y-T, Chu C-Y. Treatments for Severe Cutaneous Adverse Reactions. Abe R, editor. J Immunol Res. 2017;2017:1503709.

Kim D-H, Koh Y-I. Comparison of Diagnostic Criteria and Determination of Prognostic Factors for Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome. Allergy Asthma Immunol Res. 2014 May;6(3):216–21.

De A, Rajagopalan M, Sarda A, Das S, Biswas P. Drug Reaction with Eosinophilia and Systemic Symptoms: An Update and Review of Recent Literature. Indian J Dermatol. 2018;63(1):30–40.

Bohm KJ, Ciralsky JB, Harp JL, Bajaj S, Sippel KC. Cicatrizing Conjunctivitis in a Patient Diagnosed With Drug Reaction With Eosinophilia and Systemic Symptoms/Drug-Induced Hypersensitivity Syndrome but With Features of Stevens–Johnson Syndrome. Cornea. 2016;35(6).

Karuppannasamy D, Andavar R, Arumugam J, Muthuvel K. DRESS Syndrome Secondary to Carbamazepine Therapy Presenting with Bilateral Acute Anterior Uveitis and Angle Closure Glaucoma. J Ophthalmic Vis Res [Internet]. 2019 Jul 18;14(3):382–6. Available from: https://pubmed.ncbi.nlm.nih.gov/31660117