The Positive Impact of Vitamin C (Ascorbic Acid) Utilisation in Cancer Treatment: A Scoping Review of Published Articles From the Perspective of the in Vitro Studies

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Published: Oct 31, 2021
Keywords:
Ascorbic acid, Vitamin C, Treat cancer, Anti-cancer, in vitro study

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Nurul Ain Mohammad Hamdi
Advanced Drug Delivery Laboratory, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
Muhammad Salahuddin Haris
Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia
Ahmad Fahmi Harun Ismail
Department of Physical Rehabilitation Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia

Abstract

Survival benefit of patients with advanced cancer was reported with intravenous vitamin C administration. Nevertheless, a recent systematic review failed to support the clinically use of vitamin C in cancer patients due to the diversity of interventions and cancer type. This study aimed to provide a scoping review of vitamin C utilisation and its impact on cancer treatment from the perspective of in vitro studies. The review was conducted using predefined search terms in three scientific databases. 44 articles were retrieved with a total of 15 cancer types being studied from 2015 to 2020. The findings were classified into primary and secondary outcome. The primary outcome refers to chief consequences of vitamin C treatment, while the secondary outcome denotes the additional advantages generated as a result of the primary outcome, which occurs both in monotherapy and combination therapy. This review discussed the major mechanism of vitamin C as anti-cancer and its relation with the outcomes.

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How to Cite
Mohammad Hamdi, N. A., Haris, M. S., & Harun Ismail, A. F. (2021). The Positive Impact of Vitamin C (Ascorbic Acid) Utilisation in Cancer Treatment: A Scoping Review of Published Articles From the Perspective of the in Vitro Studies. Malaysian Journal of Medicine and Health Sciences, 17(4). Retrieved from http://mjmhsojs.upm.edu.my/index.php/mjmhs/article/view/408
Issue
Vol. 17 No. 4 (2021)
Section
Review Article

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