The Technique of Intravenous Ketamine Infusion on Post- Operative Hyperalgesia in Gluteal Sarcoma
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Abstract
Post-Operative Hyperalgesia (POH) is an uncommon painful condition suffered after surgery. It is poorly identified and usually needs a large dose of strong opioids administration to attenuate pain. Primarily POH originated from the activation of N-Methyl-DE Aspartate Receptor (NMDAR) located at the spinal cord. Hence NMDAR antagonist (ketamine) may inhibit this pain mechanism leading to desirable post-operative pain relief. We presented a case report on how to recognize POH, initiated ketamine infusion, and its limitation. We found ketamine therapy reduced opioid requirements and drastically improve patient daily bed activities.
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